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Potential Disadvantages of PD for Diabetic ESRD Patients

  • Increased retinal and glomerular capillary permeability among diabetics is also seen in the peritoneal capillaries
  • Decreased permselectivity may be due to a reduction in the fixed negative charges of the capillary basement membrane
  • High permeability results in increased amino acid and protein losses with resultant low serum albumin concentrations (a marker of malnutrition)

 

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